Comparison of Nebulized Salbutamol and Epinephrine in Acute Bronchiolitis
Abstract
ABSTRACT Background: : Bronchiolitis, known to be a common disease of the lower respiratory tract infection of infants, and there is a lot of debates in its modalities of treatment. Aim: To produce a methodical survey considering, the efficacy Of the ordinarily used medications for bronchiolitis ( Nebulized Salbutamol and epinephrine) in infants with acute bronchiolitis Patients & Methods: A prospective study on one hundred twenty patients with bronchiolitis admitted to Al- Khansa' Maternity and Children Teaching Hospital between the per the first of December 2012 till the thirtieth of April 2013. The babies who were enrolled in this study were having their 1st attack of bronchiolitis and their age was less than one year . Information were taken from their mothers including age ,sex , gestational age , residence , feeding , socioeconomic status, family history of atopy , parental smoking , number of persons per room , the presenting signs and symptoms ( fever, cough, dyspnea , cyanosis , rhinorrhea , tachypnea , apnea , poor feeding and irritability, respiratory distress ,hyperinflation , fine crepitation , wheeze ) . Chest radiography was taken to all patients. The babies assigned randomly in order to receive either (group1) nebulize adrenaline (0.5ml/kg up to a 2.5ml with 3ml normal saline) or(group2) salbutamol (0.15mg/kg with 3ml normal saline) by nebulizer along with oxygen.Results: We compare the effect of adrenaline nebulizer versus salbutamol nebulizer which revealed better effect of adrenaline over salbutamol in reducing in oxygen requirement, respiratory rate and wheeze. Most of radiological findings were air trapping and Increase vascular marking With little consolidation and collapse. Bronchiolitis was more common in low socioeconomic families and in those with parental smoking and in overcrowding areas. Breast feeding has protective role. Recommendation :in our work we recommend use of adrenalin over salbutamol but also little evidence is important to back up the habit of use of either of these drugs in the treatment of the babies with bronchiolitis. A larger, and better-designed pragmatic study on some common known interventions on bronchiolitis is important to choose an effective treatment strategy, to manage this disease.
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