Abstract

This study was conducted to find out the therapeutic effect of Omega-3 and the zinc oxide nano-loaded propylthiouracil drug in the treatment of thyroxine-induced hyperthyroidism. The re-sults show a significant increased (p<0.05) in serum of Triiodo-thyronine(T3) and Thyroxine (T4) hormones with a decreased Thyroid stimulating hormone (TSH) level in T1 group compared with the control group. On the other hand, the results showed a significant decrease (P < 0.05) in (T3) and (T4) with increased (TSH) levels in (T2, T3) groups compared to (T1) group. There was a significant (p < 0.05) increase in the level of Malondialde-hyde (MDA)with a decrease in the level of antioxidants Gluta-thione (GSH), Superoxide Dismutase (SOD), Catalase (CAT) in the (T1) group in comparison with the control group. Also, the results showed a significant (p < 0.05) decrease in the level of MDA with an increase in the level of antioxidants (GSH, SOD, CAT) in the (T2, T3) groups as compared to the (T1) group. The results of the current study showed that there was a signifi-cant increase (P < 0.05) in the level of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phospha-tase (ALP) in the (T1) group as compared to (C) group, also, these results showed a significant (p < 0.05) decrease in the level of ALP, ALT, AST in the (T2, T3) groups compared to (T1) group. Several methods were used in the examination of the drug propylthiouracil nano-loaded on zinc oxide, as they includ-ed the following tests on the Fourier transform infrared Spec-troscopy (FT – IR) and X-ray diffraction X-ray diffraction spec-trum (XRD) as well as the use of atomic force microscope Atomic Force Microscope (AFM), the process of intercalation of the drug between layers of zinc oxide was carried out by the di-rect ion exchange method. This technique showed that propylthiouracil gave spectra indicating the success of the inter-calation process, which was used in the subsequent stages of the study.

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The article was added to IASJ on 2023-06-22

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