Abstract

Background: Up to one-third of adults worldwide may have non-alcoholic fatty liver disease (NAFLD), which is a public health issue. Numerous cohort studies have repeatedly demonstrated that the main causes of death in NAFLD patients are cardiovascular diseases (CVDs), and that NAFLD (especially in its more advanced stages) is associated with a higher risk of all-cause mortality than extrahepatic tumors and liver-related issues. An expanding body of evidence indicates that NAFLD is significantly associated with an increased risk of major CVD events and other cardiac issues. (i.e., cardiomyopathy, cardiac arrhythmias, and cardiac valvular calcification), independent of conventional cardiovascular risk factors. This article provides a summary of the research on the evidence pointing to a connection between NAFLD and a higher risk of cardiovascular disease, and the impact of MDA and Antoxidants in non-alcoholic fatty liver patients and patients with coronary arteries.Objective: To know the extent to which non-alcoholic fatty liver disease effects and its relationship to coronary artery obstructive disease and assessment of MDA, TAC, GPX, and Selenium levels and their impact on both NAFLD and CAD.Materials and Methods: This study was a case-control study that included 120 samples (male and female) and their serum samples were collected from Kerbala Heart Center / Kerbala Health Directorate l Kerbala - Iraq with ages ranging between 40 to 73 years. the number of patients with coronary arteries was 60 and the number of healthy people was 60 The number of patients was 37 with non-alcoholic fatty liver disease and 23 without NAFD people in both case and control. The serum withdrawn was kept at -20 °C., The liver function test, lipid profile, and albumin were determined at optimized conditions in the laboratory of the Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala by using the Automated Biochemistry analyzer to measure liver function and examine albumin, while the MDA, TAC, and GPX biomarkers was determined by Chemical methods Selenium measured by atomic absorption.Results: The observed levels of MDA increased in non-alcoholic fatty liver disease, steatosis, and Coronary artery disease, Results indicated a significant difference in MDA level among groups, The mean levels of MDA in patient was (2.43 ± 0.90) which was significantly higher than for control group (2.15 ± 0.52), (p ≤ 0.001). The level of MDA risk factor to liver inflammation and fibrosis, whereas, and increased risk factor of chronic coronary artery disease and antioxidants were protactive in CAD. Conclusion: The results presented here contribute to the determination of the functions of the physiological MDA risk factor to the liver fat and chronic coronary artery obstructive disease, and antioxidant is decreased from NAFLD and CAD.

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The article was added to IASJ on 2023-10-30

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